International Journal of applied mathematics and computer science

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Paper details

Number 2 - June 1994
Volume 4 - 1994

Irregularity in scheduling of cancer chemotherapy

Andrzej Świerniak, Andrzej Polański

Abstract
The paper presents a problem of optimal control of a bilinear system in the plane which has irregular properties although the optimization problem is similar to . those ones which admit the "regular synthesis" (Sussman, 1987c). The number of switchings derived from the maximum principle can be arbitrarily large in any time interval and multiple solutions to the two-point. boundary-value problem are possible. An example from modelling cancer chemotherapy was derived to demonstrate irregularities.

Keywords
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